Yellow means that the actor or actress originated the role. Red means that the actor or actress replaced the original. Actors and actresses who left Passions are listed beneath the table.
| Character | Actor or Actress |
| Pilar Lopez-Fitzgerald | Eva Tamargo Lemus |
| Luis Lopez-Fitzgerald | Galen Gering |
| Theresa Lopez-Fitzgerald | Lindsay Korman |
| Miguel Lopez-Fitzgerald | Jesse Metcalfe |
| Julian Crane | Ben Masters |
| Ivy Winthrop Crane | Kim Johnston Ulrich |
| Sheridan Crane | McKenzieWestmore |
| Ethan Crane | Travis Schuldt |
| (Voice of) Alistair Crane | Voiced by Alan Oppenheimer |
| T.C. Russell | Rodney Van Johnson |
| Eve Russell | Tracey Ross |
| Whitney Russell | Brook Kerr |
| Simone Russell | Lena Cardwell |
| Sam Bennett | James Hyde |
| Hank Bennett | Dalton James |
| Grace Bennett | Dana Sparks |
| Kay Bennett | Deanna Wright |
| Jessica Bennett | Jade Harlow |
| Charity Standish | Molly Stanton |
| Angel Girl | Chea Courtney |
| Father Lonigan | Bruce French |
| Tabitha Lennox | Juliet Mills |
| Timmy | Josh Ryan Evans |
| Reese Durkee | Bruce Michael Hall |
| Chad Harris | Donn Swaby |
| Gwen Hotchkiss | Natalie Zea |
| Rebecca Hotchkiss | Andrea Evans |
| Beth Wallace | Kelli McCarty |
| Hecuba | Robin Strasser |
Actors and Actresses that left
Kelli McCarty (Beth
Wallace)-- Unsure if she left the show or just is on recurring status.
Liza Huber (Gwen
Hotchkiss)
Taylor Anne Mountz
and Gina Marie May
(Kay Bennett)
Mary Elizabeth Winstead
(Jessica Bennett)